| Player | Premier Organization | MLB Club | Year | Overall Selection |
|---|---|---|---|---|
| Kevin Ahrens | Houston Heat | Toronto Blue Jays | 2007 | 16th |
| Pedro Alvarez | Bayside Yankees | Pittsburgh Pirates | 2008 | 2nd |
| Jeff Austin | Houston Kyle Chapman | Kansas City Royals | 1998 | 4th |
| Homer Bailey | Houston Heat | Cincinnati Reds | 2004 | 7th |
| Rocco Baldelli | Bayside Yankees | Tampa Bay Devil Rays | 2000 | 6th |
| Daniel Bard | Building Champions | Boston Red Sox | 2006 | 28th |
| Kenny Baugh | Houston Kyle Chapman | Detroit Tigers | 2001 | 11th |
| Josh Beckett | Columbia Angels | Florida Marlins | 1999 | 2nd |
| Robbie Beckett | Austin Slam | San Diego Padres | 1990 | 25th |
| Lance Berkman | Austin Slam | Houston Astros | 1997 | 16th |
| Andy Brown | LIDS Indiana Bulls | New York Yankees | 1998 | 24th |
| Matt Campbell | Building Champions | Kansas City Royals | 2004 | 29th |
| Chance Caple | Dallas Mustangs | St. Louis Cardinals | 1999 | 30th |
| Michael Choice | Dallas Mustangs | Oakland Athletics | 2010 | 10 |
| Chris Clemons | Austin Slam | Chicago White Sox | 1994 | 33rd |
| Christian Colon | Austin Slam | Kansas City Royals | 2010 | 4 |
| Bubba Crosby | Houston Kyle Chapman | Los Angeles Dodgers | 1998 | 23rd |
| Jose Cruz, Jr | Houston Kyle Chapman | Seattle Mariners | 1995 | 3rd |
| Casey Daigle | Dallas Mustangs | Arizona Diamondbacks | 1999 | 31st |
| Jaff Decker | Bayside Yankees | San Diego Padres | 2008 | 42nd |
| Ross Detwiler | Rawlings Prospects | Washington Nationals | 2007 | 6th |
| Joey Devine | Kansas City Sluggers | Atlanta Braves | 2002 | 27th |
| Blake Dewitt | Rawlings Prospects | Los Angeles Dodgers | 2004 | 28th |
| Kyle Drabek | Houston Heat | Philadelphia Phillies | 2006 | 18th |
| Scott Elbert | Midwest Nationals | Los Angeles Dodgers | 2004 | 17th |
| Clint Everts | Columbia Angels | Montreal Expos | 2002 | 5th |
| Casey Fossum | Dallas Mustangs | Boston Red Sox | 1999 | 48th |
| Choo Freeman | Dallas Mustangs | Colorado Rockies | 1998 | 36th |
| Jake Gautreau | Columbia Angels | San Diego Padres | 2001 | 14th |
| Josh Girdley | Columbia Angels | Montreal Expos | 1999 | 6th |
| Greg Golson | Austin Slam | Philadelphia Phillies | 2004 | 21st |
| Ben Grieve | Dallas Mustangs | Oakland As | 1994 | 2nd |
| Craig Hansen | Bayside Yankees | Boston Red Sox | 2005 | 26th |
| Aaron Heilman | LIDS Indiana Bulls | New York Mets | 2001 | 18th |
| Phillip Humber | Dallas Mustangs | New York Mets | 2004 | 3rd |
| Tommy Hunter | LIDS Indiana Bulls | Texas Rangers | 2007 | 54th |
| Jason Jennings | Premier Titans | Colorado Rockies | 2001 | 16th |
| Steve Karsay | Bayside Yankees | Toronto Blue Jays | 1990 | 22nd |
| Scott Kazmir | Houston Heat | New York Mets | 2002 | 15th |
| Bob Keppel | Rawlings Prospects | New York Mets | 2000 | 36th |
| Billy Koch | Bayside Yankees | Toronto Blue Jays | 1996 | 4th |
| James Loney | Houston Kyle Chapman | Los Angeles Dodgers | 2002 | 19th |
| Lance Lynn | LIDS Indiana Bulls | St. Louis Cardinals | 2008 | 39th |
| Kyle Mc Culloch | Columbia Angels | Chicago White Sox | 2006 | 29th |
| Drew Meyer | Building Champions | Texas Rangers | 2002 | 10th |
| Matt Morris | Bayside Yankees | St. Louis Cardinals | 1996 | 12th |
| David Murphy | Houston Kyle Chapman | Boston Red Sox | 2003 | 17th |
| Calvin Murray | Dallas Mustangs | San Francisco Giants | 1992 | 7th |
| Jeff Niemann | Columbia Angels | Tampa Bay Devil Rays | 2004 | 4th |
| Justin O'Conner | LIDS Indiana Bulls | Tampa Bay Rays | 2010 | 31 |
| John Patterson | Dallas Mustangs | Montreal Expos | 1996 | 5th |
| Danny Peoples | Austin Slam | Cleveland Indians | 1996 | 28th |
| Scott Ruffcorn | Dallas Mustangs | Chicago White Sox | 1991 | 25th |
| Joe Savery | Houston Heat | Philadelphia Phillies | 2007 | 19th |
| Max Scherzer | Rawlings Prospects | Arizona Diamondbacks | 2006 | 11th |
| Nick Schmidt | Rawlings Prospects | San Diego Padres | 2007 | 23rd |
| Brett Sinkbeil | Midwest Nationals | Florida Marlins | 2006 | 19th |
| Huston Street | Austin Wings | Oakland As | 2004 | 40th |
| Jameson Taillon | Houston Kyle Chapman | Pittsburgh Pirates | 2010 | 2 |
| Scott Thorman | Team Ontario | Atlanta Braves | 2000 | 30th |
| Jason Tyner | Houston Kyle Chapman | New York Mets | 1998 | 21st |
| Todd Van Poppell | Dallas Mustangs | Oakland As | 1990 | 14th |
| Ryan Wagner | Houston Kyle Chapman | Cincinnati Reds | 2003 | 14th |
| Walt Weiss | Bayside Yankees | Oakland As | 1985 | 11th |
| Kip Wells | Houston Kyle Chapman | Chicago White Sox | 1998 | 16th |
| Vernon Wells | Dallas Mustangs | Toronto Blue Jays | 1997 | 5th |
| Craig Whitaker | Houston Heat | San Francisco Giants | 2003 | 34th |
| Matt Wieters | Building Champions | Baltimore Orioles | 2007 | 5th |
| Alex Wimmers | Cincy Flames | Minnesota Twins | 2010 | 21 |
| Brandon Wood | Albuquerque Baseball Academy | Anaheim Angels | 2003 | 23rd |
| Andy Yount | Houston Kyle Chapman | Boston Red Sox | 1995 | 15th |
| A. J. Zapp | LIDS Indiana Bulls | Atlanta Braves | 1996 | 27th |